Abstract: To address the problem of rapid response constellation design under regional emergencies, a constellation deployment optimization model including six objective functions is established based on the full consideration of constellation responsiveness and coverage. In the process of solving, the NSGA-NN multi-objective optimization framework for multiple scenarios was established to overcome the defects of the traditional solution methods. Experiments were conducted to analyze the NSGA-NN multi-objective optimization framework from different perspectives. The results show that the framework is extremely effective for solving the rapid response constellation optimization deployment model, which provides a new strategy and support for the design of rapid response constellations oriented to regional objectives.