Abstract: We take "Beidou enabling intelligent manufacturing more accurate" as enabling application as the starting point. Through the application of space-based resources such as Beidou satellite navigation, timing, short message communication, and technologies such as Internet of Things and cloud computing, an industrial Internet enabling platform based on Beidou spatio-temporal reference service is innovatively constructed. We solved the collaborative imprecision, non-synchronization of classification time-frequency and other hidden problems due to the lack of high-precision spatio-temporal information in the industrial Internet system. The application verification of the empowerment platform was carried out with the scenes of ocean shipping and chemical industry park. The verification results show that the Beidou time-space reference service has a significant effect on industrial Internet production and application, which achieves accurate energy efficiency management of ships and makes seamless connection and synergistic linkage between human, material and regional functional systems in the chemical industrial park.