Abstract: To improve security and real-time application of image encryption, an image encryption scheme based on generalized chaotic logic and DNA computing is proposed. Compressed sensing operation was carried out, and Logistic mapping efficient scrambling technology was used to reduce scale of chaotic value vectors for real-time image scrambling. DNA coding rules were used to convert each value into 8-bit decimal pixel value with light calculation magnitude. User study and two objective quality metrics (temporal continuity distortion measure and significant similarity measure) were used to evaluate retargeting performance, and time consumption was compared with existing algorithms. Experimental results show that the proposed scheme can greatly reduce algorithm complexity and video retargeting time without obvious reduction of retargeting video quality.